| Titre : | Can activated charcoal be used to treat obstetric cholestasis? (2020) |
| Auteurs : | Sophie Gidet |
| Type de document : | Article : texte imprimé |
| Dans : | Midirs. Midwifery Digest (Vol. 30, n° 3, September 2020) |
| Article en page(s) : | p. 338-343 |
| Langues: | Anglais |
| Sujets : |
Paramédical (MeSH) Acide ursodésoxycholique ; Acides et sels biliaires ; Charbon de bois ; Cholestase ; Cholestase intrahépatique ; Complications de la grossesse ; Obstétrique |
| Résumé : |
Obstetric cholestasis (OC), also known as intrahepatic cholestasis of pregnancy (ICP), affects up to 1.5% of pregnancies (Royal College of Obstetricians and Gynaecologists (RCOG) 2011) and can be a distressing condition for pregnant mothers as well as life-threatening to the fetus.
OC is a condition that is not well understood and current knowledge of drug therapies is equally limited as a result. The current preferred treatment option, ursodeoxycholic acid (UDCA), is not entirely satisfactory, because there is limited knowledge on how it affects the fetus and it offers no guaranteed protection against stillbirth (RCOG 2011). Kaaja et al (1994) conducted a preliminary randomised control study (RCT) on the use of activated charcoal (AC) to treat OC. The results showed that AC could significantly reduce levels of bile acids, and these, in excessive amounts, are thought to be the cause of maternal itching and fetal demise (Bothamley & Boyle 2009). The Kaaja et al study (1994) was small and involved few participants; more studies are needed to expand clinicians' knowledge-base of AC and to increase understanding of its potential use for therapy in OC-complicated pregnancies. |
Exemplaires (1)
| Localisation | Section | Support | Cote de rangement | Statut | Disponibilité |
|---|---|---|---|---|---|
| Bibliothèque Paramédicale | Périodiques | Périodique | MID. DIG. 20-3 | Empruntable | Disponible |
